Mineralogical-geochemical (SIMS method) study of titanite and geochronological (ID-TIMS method) study of garnets from mineral mines of the Southern Urals has been carried out. The mineral associations containing titanite belong to four contrasting types: epidote-titanite-garnet (Akhmatovskaya mine); garnet-titanite-diopside (Akhmatovskaya mine); epidote-titanite-chlorite (Nikolaje-Maksimilianovskaya mine); chlorite-titanite-garnet (Praskovie-Evgenyevskaya mine). Titanite from mineral aggregates of the Akhmatovskaya mine is enriched with LREE and Th, Nikolaje-Maksimilianovskaya mine – with HREE, Hf and Ta, Praskovie-Evgenyevskaya mine – with V, Cr, and Sr. It was found that the distribution of trace and rare-earth elements in titanite is related both to the composition of paragenetic minerals (garnet and epidote, Akhmatovskaya and Nikolaje-Maksimilianovskaya mines) and to the influence of rock-forming minerals of the parent rock – gabbro (plagioclase and pyroxene, Praskovie-Evgenyevskaya mine). The age of garnets (504.1±4 Ma) determined by ID-TIMS method from silicate-carbonate rocks of the Perovskitovaya mine does not agree with the ideas about the formation of the latter as a result of contact metasomatosis synchronous with the introduction of gabbroids or granitoids of the Kusa-Kopan complex (1,390-1,350 Ma), but does not exclude the influence of superimposed contact metasomatosis associated with late endogenous processes.