The article considers the conditions of lithification in sedimentary basins at different stages of lithogenesis. It is shown that lithification is crucial in the formation of elisional regime in artesian structures. After this process elisional regime of artesian structures descends. Lithification of rocks mostly at the stage of catagenesis and metagenesis generally lead to disturbance of the normal hydrogeochemical zoning in the deep parts of the section of artesian structures creating a hydrogeochemical inversion (desalination) in aquifers.