The estimation of main factors which exerts influence upon functioning reliability of system «tunnels – underground space» is executed. It is shown that hydrogeological conditions have a special importance for construction and maintenance of subway tunnels in Saint-Petersburg. The hydrodynamic effect of regional and local water-bearing horizons on development and activation of different processes such as groundwaters flow, quicksands, head water inrush, underground constructions deformation is analyzed. The influence of hydrochemical conditions on formation of underground space aggressiveness to constructional and waterproofing materials of the tunnels is established. The negative effect of underground microbiota activity on degradation of reinforced concrete and castiron tunnel lining is shown.