The article addresses one of the most important aspects of territorial planning - the location of productive forces in the region. The influence of the results of this type of activity on the development of the country's economy and increasing the investment attractiveness of the region's territory is considered. The author characterizes the process of placing productive forces in the region and reveals its shortcomings associated with insufficient consideration of environment-forming and environmental factors. We give recommendations on the transition to new principles of development and location of productive forces in the region with reasonable consideration of socio-ecological factors, which will contribute to a more harmonious development of the territory with the preservation of natural systems.