Modern methods of hydrocarbon field development with horizontal wells require high accuracy of oil and gas wells. ZIS-4M (MAK-170) telemetry systems with highly reliable hard-fixed sensors of angle measurements (zenith angle, whipstock position angle and azimuthal angle) and organization of electromagnetic bottom-hole communication channel at very low frequencies are used for drilling such wells. Integration and computer processing of downhole measurements with measurements of drilling parameters made by surface sensors, express- investigations of drilling mud and cuttings parameters increase informative character of geological section investigations and provide optimization of drilling process in complicated geological conditions. Examples of work organization with the use of an automated system of operational control of drilling technology and wellbore trajectory, allowing with high accuracy and reliability to conduct horizontal sections of drilling wells in productive formations, including low thickness formations, are described.