Possible approaches to the development of high-intensity low-discharge processes of biodegradation of organic pollutants based on hybrid technologies with simultaneous action of aggressive chemical and photochemical agents and microorganisms, resistant to oxidative stress, have been studied. Such processes, in principle, can be focused on the development of environmentally friendly technologies for decontamination of sludge from petrochemical enterprises, low-radioactive cellulose- and polymer-containing waste from nuclear power plants, etc.