The risk of endogenous fires at the mines of Southern Kuzbass, developing mainly coal seams prone to spontaneous combustion, is quite high. The occurrence of underground fires leads to significant material losses, both direct and for emergency rescue work. The data on the volumes of production from thick seams at the mines of OJSC UCC Yuzhkuzbassugol and on the number of endogenous fires in recent years are given. A comprehensive system of measures to prevent and extinguish endogenous fires at the stage of design, development of the mining area passport, mining and isolation of the mined-out space is proposed. Application of the system will significantly reduce the risk of spontaneous combustion of coal, ensure the safety of mining coal seams prone to spontaneous combustion, and significantly reduce material losses associated with extinguishing endogenous fires.