Consideration of geodynamic, hydrogeochemical, erosion and other quantitative characteristics describing evolutionary processes in a rock mass is carried out when choosing a geological formation for the disposal of radioactive waste. However, the role of various process parameters is not equal for safety ensuring and additional percentages of measurement accuracy are far from always being of fundamental importance. This makes it necessary to identify various types of indicators of the geological environment that determine the safety of radioactive waste disposal for their detailed study in the conditions of the burial site. An approach is proposed to determine the priority indicators of physical processes in the rock mass that determine the safety of disposal of various types of radioactive waste and require increased attention (accuracy, frequency of measurements) when determining in-situ conditions. To identify such factors, we used the sensitivity analysis method that is a system change in the limits of variable values during security modeling in order to assess their impact on the final result and determine the role of various physical processes in ensuring safety. It is shown that the safety of isolation depends on various factors when burying "natural", "short-lived", and "long-lived" groups of nuclides. The factors that greatly affect safety when disposing of radioactive waste of these types are highlighted. The list of parameters of the geological environment that characterize the priority mechanisms of localization of various types of radionuclide contamination during burial and requiring the most detailed determination in full-scale conditions is defined.
