The paper studies seismicity of the South Polar Region from the South Pole to the 50th parallel of south latitude. During the observation period, earthquakes of various genesis with a magnitude of M > 8 occurred in seismically hazardous zones of the Southern Ocean – the South Sandwich subduction zone, the Macquarie Ridge and the Antarctic Ridge. These events can cause significant tsunamis. The Macquarie Ridge is characterized by a shear mechanism of the earthquake source, while different mechanisms were obtained for the Sandwich subduction zone region. During the instrumental observation period, weak intracontinental seismicity of Antarctica was recorded, which refutes the position of aseismicity of this continent. Seismicity is observed at the boundaries of tectonic blocks or is confined to coastal areas. In the continental intraplate region of Antarctica, earthquakes occur in several settings. The events in the Transantarctic Mountains and some subglacial rift basins, as well as isolated events in the central part of the continent, are probably tectonic. Seismicity in the coastal zone and on the continental margin may be related to glacial isostatic adjustment with a regional tectonic component in some places. The seismicity observed in Antarctica is low compared to other continental intraplate regions. The strongest events within the continent have a magnitude of 5-6. The authors identified intracontinental areas of increased seismicity. A correlation between intracontinental seismicity and subglacial basins of East Antarctica is shown. Some events with magnitudes below the threshold are not recorded. In addition, seismicity is partially suppressed by a thick ice cover.