2411-3336 2541-9404 Записки Горного института Journal of Mining Institute Санкт-Петербургский горный университет императрицы Екатерины ΙΙ Empress Catherine II Saint Petersburg Mining University 10.31897/PMI.2022.9 pmi-15604 https://pmi.spmi.ru/pmi/article/view/15604 Геотехнология и инженерная геология Geotechnical Engineering and Engineering Geology Production of microfluidic chips from polydimethylsiloxane with a milled channeled surface for modeling oil recovery during porous rock waterflooding Изготовление микрофлюидных чипов из полидиметилсилоксана с фрезерованной канализированной поверхностью для моделирования нефтеотдачи при заводнении пористой породы Yakimov Anton S. Якимов А. С. Yakimov Anton S. asyakimov@gmail.com 0000-0003-4919-9877 Сибирский федеральный университет (Россия) Siberian Federal University (Russia) Pryazhikov Andrey I. Пряжников А. И. Pryazhikov Andrey I. apryazhnikov@sfu-kras.ru 0000-0002-6124-037X Сибирский федеральный университет (Россия) Siberian Federal University (Russia) Pryazhikov Maxim I. Пряжников М. И. Pryazhikov Maxim I. mpryazhnikov@sfu-kras.ru 0000-0001-9143-7950 Сибирский федеральный университет (Россия) Siberian Federal University (Russia) Minakov Andrey V. Минаков А. В. Minakov Andrey V. tov-andrey@yandex.ru 0000-0003-1956-5506 Сибирский федеральный университет (Россия) Siberian Federal University (Russia) 29 04 2022 2022 253 105 114 16 09 2021 24 02 2022 29 04 2022 © 2022 А. С. Якимов, А. И. Пряжников, М. И. Пряжников, А. В. Минаков © 2022 Anton S. Yakimov, Andrey I. Pryazhikov, Maxim I. Pryazhikov, Andrey V. Minakov 2022 А. С. Якимов, А. И. Пряжников, М. И. Пряжников, А. В. Минаков Anton S. Yakimov, Andrey I. Pryazhikov, Maxim I. Pryazhikov, Andrey V. Minakov Эта статья доступна по лицензии Creative Commons Attribution 4.0 International (CC BY 4.0) This article is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0) https://pmi.spmi.ru/pmi/article/view/15604

Для изучения течения нефтесодержащей эмульсии в породе используются микрофлюидные чипы с пористыми структурами. Такие чипы можно изготавливать из полидиметилсилоксана методом отливки в мастер-форму. На начальных этапах исследований зачастую требуется быстрое и дешевое прототипирование большого количества различных мастер-форм. Предлагается использовать фрезеровку для изготовления канализированной поверхности на пластинке полиметилметакрилата, с которой нужно снимать негативный оттиск, являющийся мастер-формой для отливки в нем позитивных чипов из полидиметилсилоксана. Проверено несколько эпоксидных составов для изготовления такой мастер-формы. Основным требованием при поиске материала было точное повторение геометрии и достаточно низкая адгезия к полиметилметакрилату и полидиметилсилоксану для выемки изделия с минимальными повреждениями формы. Из всех используемых материалов удалось изготовить мастер-формы, но с дефектами и различной степенью поврежденности. Один из эпоксидных составов признан пригодным для изготовления мастер-формы со множеством элементов, имитирующих зерна пористой среды (отношение высоты к ширине 2:3). Разработанный метод позволяет использовать полидиметилсилоксан для прототипирования чипов, моделирующих пористую структуру нефтесодержащей породы.

Microfluidic chips with porous structures are used to study the flow of oil-containing emulsion in the rock. Such chips can be made from polydimethylsiloxane by casting into a master mold. At the initial stages of research, fast and cheap prototyping of a large number of different master molds is often required. It is proposed to use milling to make a channeled surface on a polymethyl methacrylate plate, from which a negative image should be taken, which is the master mold for casting positive polydimethylsiloxane chips in it. Several epoxy compositions have been tested to make this master mold. The main requirement in the search for the material was the exact replication of the geometry and sufficiently low adhesion to polymethyl methacrylate and polydimethylsiloxane for removing the product with minimal damage to the mold. It was possible to make master molds from all the materials used, but with defects and various degrees of damage. One of the epoxy compositions was found suitable for making a master mold with many elements simulating the grains of a porous medium (height to width ratio 2:3). The developed method makes it possible to use polydimethylsiloxane for prototyping chips simulating the porous structure of an oil rock.

 Ключевые слова микрофлюидная модель пористой среды микрофрезерование изготовление негативной мастер-формы нефтеотдача при заводнении остаточная нефтенасыщенность полиметилметакрилат полидиметилсилоксан Keywords porous medium microfluidic model micro-milling negative master mold making oil recovery during flooding residual oil saturation polymethyl methacrylate polydimethylsiloxane Bazazi P., Sanati-Nezhad A., Hejazi S.H. Role of chemical additives on water-based heavy oil mobilization: A microfluidic approach // Fuel. 2019. Vol. 241. P. 1195-1202. DOI: 10.1016/j.fuel.2018.12.099 Bazazi P., Sanati-Nezhad A., Hejazi S.H. Role of chemical additives on water-based heavy oil mobilization: A microfluidic approach. Fuel. 2019. Vol. 241, p. 1195-1202. DOI: 10.1016/j.fuel.2018.12.099 Joseph J., Gunda S.K., Mitra S.K. On-chip porous media: Porosity and permeability measurements // Chemical Engineering Science. 2013. Vol. 99. P. 274-283. DOI: 10.1016/j.ces.2013.05.065 Joseph J., Gunda S.K., Mitra S.K. On-chip porous media: Porosity and permeability measurements. Chemical Engineering Science. 2013. Vol. 99, p. 274-283. DOI: 10.1016/j.ces.2013.05.065 Vavra E.D., Yongchao Zeng, Siyang Xiao et al. Microfluidic devices for characterizing pore-scale event processes in porous media for oil recovery applications // Journal of Visualized Experiments. 2018. Vol. 131. № e56592. DOI: 10.3791/56592 Vavra E.D., Yongchao Zeng, Siyang Xiao et al. Microfluidic devices for characterizing pore-scale event processes in porous media for oil recovery applications. Journal of Visualized Experiments. 2018. Vol. 131. N e56592. DOI: 10.3791/56592 Saadat M., Yang J., Dudek M. et al. Microfluidic investigation of enhanced oil recovery: The effect of aqueous floods and network wettability // Journal of Petroleum Science and Engineering. 2021. Vol. 203. № 108647. DOI: 10.1016/j.petrol.2021.108647 Saadat M., Yang J., Dudek M. et al. Microfluidic investigation of enhanced oil recovery: The effect of aqueous floods and network wettability. Journal of Petroleum Science and Engineering. 2021. Vol. 203. N 108647. DOI: 10.1016/j.petrol.2021.108647 Fuwei Yu, Hanqiao Jiang, Fei Xu et al. New insights into flow physics in the EOR process based on 2.5D reservoir, micromodels // Journal of Petroleum Science and Engineering. 2019. Vol. 181. № 106214. DOI: 10.1016/j.petrol.2019.106214 Fuwei Yu, Hanqiao Jiang, Fei Xu et al. New insights into flow physics in the EOR process based on 2.5D reservoir, micromodels. Journal of Petroleum Science and Engineering. 2019. Vol. 181. N 106214. DOI: 10.1016/j.petrol.2019.106214 Гладких Е.А., Галкин В.И., Хижняк Г.П. Влияние фильтрационно-емкостных свойств объектов разработки на величину коэффициента вытеснения нефти в различных геолого-физических условиях // Известия Томского политехнического университета. Инжиниринг георесурсов. 2018. Т. 329. № 7. С. 77-85. Gladkikh E.A., Khizhnyak G.P., Galkin V.I. Influence of Filtration Capacitive Properties of Development Objects on the Value of Oil Displacement Efficiency in Various Geological and Physical Conditions. Bulletin of the Tomsk Polytechnic University. Geo Аssets Engineering. 2018. Vol. 329. N 7, p. 77-85 (in Russian). Гладких Е.А., Хижняк Г.П., Галкин В.И. Оценка коэффициента вытеснения нефти на основе стандартных исследований керна месторождений Пермского края // Нефтяное хозяйство. 2017. № 8. С. 90-93. DOI: 10.24887/0028-2448-2017-8-90-93 Gladkikh E.A., Galkin V.I., Khizhniak G.P. The Method for Estimating the Oil Displacement Coefficient Based on Standard Core Analysis. Oil Industry. 2017. N 8, p. 90-93 (in Russian). DOI: 10.24887/0028-2448-2017-8-90-93 Das A., Mohanty K., Nguyen Q. A pore-scale study of foam-microemulsion interaction during low tension gas flooding using microfluidics – Tertiary recovery // Journal of Petroleum Science and Engineering. 2021. Vol. 203. № 108596. DOI: 10.1016/j.petrol.2021.108596 Das A., Mohanty K., Nguyen Q. A pore-scale study of foam-microemulsion interaction during low tension gas flooding using microfluidics – Tertiary recovery. Journal of Petroleum Science and Engineering. 2021. Vol. 203. N 108596. DOI: 10.1016/j.petrol.2021.108596 Elyaderani S.M.G., Jafari A. Microfluidics experimental study in porous media applied for nanosilica/alkalineflooding // Journal of Petroleum Science and Engineering. 2019. Vol. 173. P. 1289-1303. DOI: 10.1016/j.petrol.2018.08.039 Elyaderani S.M.G., Jafari A. Microfluidics experimental study in porous media applied for nanosilica/alkalineflooding. Journal of Petroleum Science and Engineering. 2019. Vol. 173, p. 1289-1303. DOI: 10.1016/j.petrol.2018.08.039 Huiyu Wang, Bei Wei, Zezheng Sunet et al. Microfluidic study of heavy oil emulsification on solid surface // Chemical Engineering Science. 2021. Vol. 246. № 117009. DOI: 10.1016/j.ces.2021.117009 Huiyu Wang, Bei Wei, Zezheng Sunet et al. Microfluidic study of heavy oil emulsification on solid surface. Chemical Engineering Science. 2021. Vol. 246. N 117009. DOI: 10.1016/j.ces.2021.117009 Lin Y.J., He P., Tavakkoli M. et al. Examining asphaltene solubility on deposition in model porous media // Langmuir. 2016. Vol. 32. Iss. 34. P. 8729-8734. DOI: 10.1021/acs.langmuir.6b02376 Lin Y.J., He P., Tavakkoli M. et al. Examining asphaltene solubility on deposition in model porous media. Langmuir. 2016. Vol. 32. Iss. 34, p. 8729-8734. DOI: 10.1021/acs.langmuir.6b02376 Martyushev D.A., Vinogradov J. Development and application of a double action acidic emulsion for improved oil well performance: laboratory tests and field trials // Colloids and Surfaces A: Physicochemical and Engineering Aspects. 2021. Vol. 612. № 125998. DOI: 10.1016/j.colsurfa.2020.125998 Martyushev D.A., Vinogradov J. Development and application of a double action acidic emulsion for improved oil well performance: laboratory tests and field trials. Colloids and Surfaces A: Physicochemical and Engineering Aspects. 2021. Vol. 612. N 125998. DOI: 10.1016/j.colsurfa.2020.125998 Martyushev D.A., Govindarajan S.K. Development and study of a visco-elastic gel with controlled destruction times for killing oil wells // Journal of King Saud University – Engineering Sciences. 2021. DOI: 10.1016/j.jksues.2021.06.007 Martyushev D.A., Govindarajan S.K. Development and study of a visco-elastic gel with controlled destruction times for killing oil wells. Journal of King Sand University – Engineering Sciences. 2021. DOI: 10.1016/j.jksues.2021.06.007 Дерендяев Р.А., Захаров Л.А., Мартюшев Д.А., Дерендяев К.А. Повышение эффективности применения технологии по ограничению водопритока на основании геолого-физических характеристик пластов (на примере месторождений Пермского края) // Известия Томского политехнического университета. Инжиниринг георесурсов. 2019. Т. 330. № 9. С. 154-163. DOI: 10.18799/24131830/2019/9/2264 Derendyaev R.A., Zakharov L.A., Martyushev D.A., Derendyaev K.A. Improving the Efficiency of Application of Technology on Water Performance Limitation Based on Geological and Physical Characteristics of the Plates (on the Example of Deposits of the Perm Region). Bulletin of the Tomsk Polytechnic University. Geo Аssets Engineering. 2019. Vol. 330. Iss. 9, p. 154-163 (in Russian). DOI: 10.18799/24131830/2019/9/2264 Song W., de Haas T.W., Fadaei H., Sinton D. Chip-off-the-old-rock: the study of reservoir-relevant geological processes with real-rock micromodels // Lab on a Chip. 2014. Vol. 14. Iss. 22. P. 4382-4390. DOI: 10.1039/C4LC00608A Song W., de Haas T.W., Fadaei H., Sinton D. Chip-off-the-old-rock: the study of reservoir-relevant geological processes with real-rock micromodels. Lab on a Chip. 2014. Vol. 14. Iss. 22, p. 4382-4390. DOI: 10.1039/C4LC00608A Safari A., Rashidi F., Kazemzadeh E., Hassani A. Determining optimum acid injection rate for a carbonate gas reservoir and scaling the result up to the field conditions: A case study // Journal of Natural Gas Science and Engineering. 2014. Vol. 20. P. 2-7. DOI: 10.1016/j.jngse.2014.05.017 Safari A., Rashidi F., Kazemzadeh E., Hassani A. Determining optimum acid injection rate for a carbonate gas reservoir and scaling the result up to the field conditions: A case study. Journal of Natural Gas Science and Engineering. 2014. Vol. 20, p. 2-7. DOI: 10.1016/j.jngse.2014.05.017 Xiaqing Li, Guicai Zhang, Jijiang Ge. Potential formation damage and mitigation methods using seawater-mixed acid to stimulate sandstone reservoir // Journal of Natural Gas Science and Engineering. 2016. Vol. 35. P. 11-20. DOI: 10.1016/j.jngse.2016.08.034 Xiaqing Li, Guicai Zhang, Jijiang Ge. Potential formation damage and mitigation methods using seawater-mixed acid to stimulate sandstone reservoir. Journal of Natural Gas Science and Engineering. 2016. Vol. 35, p. 11-20. DOI: 10.1016/j.jngse.2016.08.034 Xuezhi Zhao, Yujun Feng, Guangzhi Liao, Weidong Li. Visualizing in-situ emulsification in porous media during surfactant flooding: A microfluidic study // Journal of Colloid and Interface Science. 2020. Vol. 578. P. 629-640. DOI: 10.1016/j.jcis.2020.06.019 Xuezhi Zhao, Yujun Feng, Guangzhi Liao, Weidong Li. Visualizing in-situ emulsification in porous media during surfactant flooding: A microfluidic study. Journal of Colloid and Interface Science. 2020. Vol. 578, p. 629-640. DOI: 10.1016/j.jcis.2020.06.019 Xiaolong Peng, Xiangzeng Wang, Xiang Zhou et al. Lab-on-a-chip systems in imbibition processes: A review and applications/issues for studying tight formations // Fuel. 2021. Vol. 306. № 121603. DOI: 10.1016/j.fuel.2021.121603 Xiaolong Peng, Xiangzeng Wang, Xiang Zhou et al. Lab-on-a-chip systems in imbibition processes: A review and applications/issues for studying tight formations. Fuel. 2021. Vol. 306. N 121603. DOI: 10.1016/j.fuel.2021.121603 Temiz Y., Lovchik R.D., Kaigala G.V., Delamarche E. Lab-on-a-chip devices: How to close and plug the lab? // Microelectronic Engineering. 2015. Vol. 132. P. 156-175. DOI: 10.1016/j.mee.2014.10.013 Temiz Y., Lovchik R.D., Kaigala G.V., Delamarche E. Lab-on-a-chip devices: How to close and plug the lab? Microelectronic Engineering. 2015. Vol. 132, p. 156-175. DOI: 10.1016/j.mee.2014.10.013 Ríos Á., Zougagh M., Avila M. Miniaturization through lab-on-a-chip: Utopia or reality for routine laboratories? A review // Analytica Chimica Acta. 2012. Vol. 740. P. 1-11. DOI: 10.1016/j.aca.2012.06.024 Ríos Á., Zougagh M., Avila M. Miniaturization through lab-on-a-chip: Utopia or reality for routine laboratories? A review. Analytica Chimica Acta. 2012. Vol. 740, p. 1-11. DOI: 10.1016/j.aca.2012.06.024 Посмитная Я.С., Букатин А.С., Макаров Д.А. и др. Альтернативные подходы при создании мастер-форм для изготовления микрофлюидных чипов методом «мягкой» литографии // Научное приборостроение.2017. Т. 27. № 2. С. 13-20. DOI: 10.18358/np-27-2-i1320 Posmitnaya Y.S., Bukatin А.S., D.А. Makarov et al. Alternative Solutions of Master Molds Creation for Fabrication Microfluidic Chips by “Soft” Lithography. Nauchnoe priborostroenie. 2017. Vol. 27. N 2, p. 13-20 (in Russian). DOI: 10.18358/np-27-2-i1320 Gale B.K., Jafek A.R., Lambert C.J. et al. A review of current methods in microfluidic device fabrication and future commercialization prospects // Inventions. 2018. Vol. 3. Iss. 3. № 60. DOI: 10.3390/inventions3030060 Gale B.K., Jafek A.R., Lambert C.J. et al. A review of current methods in microfluidic device fabrication and future commercialization prospects. Inventions. 2018. Vol. 3. Iss. 3. N 60. DOI: 10.3390/inventions3030060 Alrifaiy A., Lindahl O.A., Ramser K. Polymer-based microfluidic devices for pharmacy, biology and tissue engineering // Polymers. 2012. Vol. 4. Iss. 4. P. 1349-1398. DOI: 10.3390/polym4031349 Alrifaiy A., Lindahl O.A., Ramser K. Polymer-based microfluidic devices for pharmacy, biology and tissue engineering. Polymers. 2012. Vol. 4. Iss. 4, p.1349-1398. DOI: 10.3390/polym4031349 Behroodi E., Latifi H., Bagheri Z. et al. A combined 3D printing/CNC micro-milling method to fabricate a large-scale microfluidic device with the small size 3D architectures: an application for tumor spheroid production // Scientific Reports. 2020. Vol. 10. Iss. 1. P. 1-14. DOI: 10.1038/s41598-020-79015-5 Behroodi E., Latifi H., Bagheri Z. et al. A combined 3D printing/CNC micro-milling method to fabricate a large-scale microfluidic device with the small size 3D architectures: an application for tumor spheroid production. Scientific Reports. 2020. Vol. 10. Iss. 1, p. 1-14. DOI: 10.1038/s41598-020-79015-5 Guckenberger D.J., de Groot T.E., Wan A.M.D. et al. Micromilling: a method for ultra-rapid prototyping of plastic microfluidic devices // Lab on a Chip. 2015. Vol. 15. Iss. 11. P. 2364-2378. DOI: 10.1039/C5LC00234F Guckenberger D.J., de Groot T.E., Wan A.M.D. et al. Micromilling: a method for ultra-rapid prototyping of plastic microfluidic devices. Lab on a Chip. 2015. Vol. 15. Iss. 11, p. 2364-2378. DOI: 10.1039/C5LC00234F Евстрапов А.А., Лукашенко Т.А., Горный С.Г., Юдин К.В. Микрофлюидные чипы из полиметилметакрилата: метод лазерной абляции и термического связывания //Научное приборостроение. 2005. Т. 15. № 2. С. 72-81. Evstrapov A.A., Lukashenko T.A., Gorny S.G., Yudin K.V. Microfluidic Chips in Poly (Methyl Methacrylate): Method of Laser Ablation and Thermal Binding. Nauchnoe priborostroenie. 2005. N 2, p. 72-81 (in Russian). Germash N.N., Esikova N.A., Afonicheva P.K., Evstrapov A.A. Research of replication accuracy in some elastomer materials with different Young’s modulus // International Conference PhysicA.SPb/2021, 18-22 October 2021, Saint Petersburg, Russia. Journal of Physics: Conference Series. 2021. Vol. 2103. № 012054. DOI: 10.1088/1742-6596/2103/1/012054 Germash N.N., Esikova N.A., Afonicheva P.K., Evstrapov A.A. Research of replication accuracy in some elastomer materials with different Young’s modulus. International Conference PhysicA.SPb/2021, 18-22 October 2021, Saint Petersburg, Russia. Journal of Physics: Conference Series. 2021. Vol. 2103. N 012054. DOI: 10.1088/1742-6596/2103/1/012054 Букатин A.С., Мухин И.С., Малышев Е.И. и др. Особенности формирования микроструктур с высоким аспектным соотношением при изготовлении полимерных микрофлюидных чипов для исследования единичных живых клеток in vitro // Журнал технической физики. 2016. Т. 86. № 10. С. 125-130. Bukatin A.S., Mukhin I.S., Malyshev E.I. et al. Fabrication of High-Aspect-Ratio Microstructures In Polymer Microfluid Chips For In Vitro Single-Cell Analysis. Technical Physics. 2016. Vol. 61. N 10, p. 1566-1571. Isiksacan Z., Guler M.T., Aydogdu B. et al. Rapid fabrication of microfluidic PDMS devices from reusable PDMS molds using laser ablation // Journal of Micromechanics and Microengineering. 2016. Vol. 26. № 3. № 035008. DOI: 10.1088/0960-1317/26/3/035008 Isiksacan Z., Guler M.T., Aydogdu B. et al. Rapid fabrication of microfluidic PDMS devices from reusable PDMS molds using laser ablation. Journal of Micromechanics and Microengineering. 2016. Vol. 26. N 3. N 035008. DOI: 10.1088/0960-1317/26/3/035008 ЯкимовА.С., ОсиповаЕ.Д., МоргунА.В. идр. Измерительная микрофлюидная система для культивирования клеток головного мозга млекопитающих // Научное приборостроение. 2019. Т. 29. № 4. С. 51-56. DOI: 10.18358/np-29-4-i5156 Yakimov A.S., Osipova E.D., Morgun A.V. et al. Measuring Microfluidic System for the Mammalian Brain Cells Cultivation. Nauchnoe priborostroenie. 2019. Vol. 29. Iss. 4, p. 51-56 (in Russian). DOI: 10.18358/np-29-4-i5156 Лукашенко Т.А., Тупик А.Н., Рудницкая Г.Е. и др. Способы спекания, склеивания и химической сварки растворителем при изготовлении полимерных и полимер-стеклянных микрочиповых устройств // Научное приборостроение. 2016. Т. 26. № 2. С. 64-74. Lukashenko T.A., Tupik A.N., Rudnitskaya G.E. et al. Thermal, Adhesive and Solvent Bonding Techniques for Polymer and Polymer-Glass Microchip Device Fabrication. Nauchnoe priborostroenie. 2016. Vol. 26. N 2, p. 64-74 (in Russian). Bamshad A., Nikfarjam A., Khaleghi H. A new simple and fast thermally-solvent assisted method to bond PMMA–PMMA in micro-fluidics devices // Journal of Micromechanics and Microengineering. 2016. Vol. 26. № 6. № 065017. DOI: 10.1088/0960-1317/26/6/065017 Bamshad A., Nikfarjam A., Khaleghi H. A new simple and fast thermally-solvent assisted method to bond PMMA–PMMA in micro-fluidics devices. Journal of Micromechanics and Microengineering. 2016. Vol. 26. N 6. N 065017. DOI: 10.1088/0960-1317/26/6/065017 Faghih M.M., Sharp M.K. Solvent-based bonding of PMMA–PMMA for microfluidic applications // Microsystem Technologies. 2019. Vol. 25. Iss. 9. P. 3547-3558. DOI: 10.1007/s00542-018-4266-7 Faghih M.M., Sharp M.K. Solvent-based bonding of PMMA–PMMA for microfluidic applications. Microsystem Technologies. 2019. Vol. 25. Iss. 9, p. 3547-3558. DOI: 10.1007/s00542-018-4266-7 Chia-Wen Tsao, DeVoe D.L. Bonding of thermoplastic polymer microfluidics // Microfluidics and nanofluidics. 2009. Vol. 6. Iss. 1. P. 1-16. DOI: 10.1007/s10404-008-0361-x Chia-Wen Tsao, DeVoe D.L. Bonding of thermoplastic polymer microfluidics. Microfluidics and nanofluidics. 2009. Vol. 6. Iss. 1, p. 1-16. DOI: 10.1007/s10404-008-0361-x Haubert K., Drier T., Beebe D. PDMS bonding by means of a portable, low-cost corona system // Lab on a Chip. 2006. Vol. 6. Iss. 12. P. 1548-1549. DOI: 10.1039/B610567J Haubert K., Drier T., Beebe D. PDMS bonding by means of a portable, low-cost corona system. Lab on a Chip. 2006. Vol. 6. Iss. 12, p. 1548-1549. DOI: 10.1039/B610567J Alroudhan A., Vinogradov J., Jackson M.D. Zeta potential of intact natural limestone: Impact of potential-determining ions Ca, Mg and SO4 // Colloids and Surfaces A: Physicochemical and Engineering Aspects. 2016. Vol. 493. P. 83-98. DOI: 10.1016/j.colsurfa.2015.11.068 Alroudhan A., Vinogradov J., Jackson M.D. Zeta potential of intact natural limestone: Impact of potential-determining ions Ca, Mg and SO4. Colloids and Surfaces A: Physicochemical and Engineering Aspects. 2016. Vol. 493, p. 83-98. DOI: 10.1016/j.colsurfa.2015.11.068 Khayrullin M.M., Zakirov T.R., Grishin P.A. et al. Methods for Studying Two-Phase Flows in Porous Media: Numerical Simulation and Experiments on Microfluidics Chips // SPE Russian Petroleum Technology Conference. 2020. DOI: 10.2118/202022-MS Khayrullin M.M., Zakirov T.R., Grishin P.A. et al. Methods for Studying Two-Phase Flows in Porous Media: Numerical Simulation and Experiments on Microfluidics Chips. SPE Russian Petroleum Technology Conference. 2020. DOI: 10.2118/202022-MS Игнатчик М.М., Посмитная Я.С., Евстрапов А.А. Исследование изменения свойств смачивания поверхности полидиметилсилоксана и канала микрофлюидного чипа после воздействия высокочастотной плазмой в среде кислорода // Научное приборостроение. 2016. Т. 26. № 1. C. 41-46. DOI: 10.18358/np-26-1-i4146 Ignatchik M.M., Posmitnaya Y.S., Evstrapov A.A. Study of Modification Wetting Properties of the Surface of Polydimethylsiloxane and the Microchannel after Exposure by High-Frequency Plasma in Oxygen. Nauchnoe priborostroenie. 2016. Vol. 26. N 1, p. 41-46. DOI: 10.18358/np-26-1-i4146 Zhou J., Ellis A.V., Voelcker N.H. Recent developments in PDMS surface modification for microfluidic devices // Electrophoresis. 2010. Vol. 31. Iss. 1. P. 2-16. DOI: 10.1002/elps.200900475 Zhou J., Ellis A.V., Voelcker N.H. Recent developments in PDMS surface modification for microfluidic devices. Electrophoresis. 2010. Vol. 31. Iss. 1, p. 2-16. DOI: 10.1002/elps.200900475 Dong Qin, Younan Xia, Whitesides G.M. Soft lithography for micro-and nanoscale patterning // Nature protocols. 2010. Vol.5. № 3. P. 491-502. DOI: 10.1038/nprot.2009.234 Dong Qin, Younan Xia, Whitesides G.M. Soft lithography for micro-and nanoscale patterning. Nature protocols. 2010. Vol. 5. N 3, p. 491-502. DOI: 10.1038/nprot.2009.234