Rational planning of measures to prevent or minimize injuries and occupational diseases at mining enterprises is associated primarily with the need for economic assessment of their consequences. A number of studies are devoted to the development of methods for determining the economic consequences of injuries and occupational diseases, which do not reflect modern approaches to social insurance against accidents at work and occupational diseases established by the relevant federal law. The economic indicators used for damage assessment need certain clarification. A method of determining the economic damage from injuries and occupational diseases on the basis of the indicator of lost profits of the enterprise is proposed.