Theoretical aspects of ecological security of the region are described. The most important factors of anthropogenic impacts on biosphere resources are considered. Based on the study of scientific literature are given definitions of such concepts as nature management, rational and irrational use of nature, environmental security. The technogenic and biospheric concepts of ecological safety according to which the system of measures to protect the environment is defined, are considered. The main directions of measures to ensure environmental security in the region are described, and the system of actions that need to be taken to ensure a sustainable state of environmental protection is considered.